Non-platinum Gemcitabine-based Combination Chemotherapy

868peffectiveness of Combination Gemcitabine/paclitaxel after Failure of Platinum-based Chemotherapy for Metastatic Urothelial Cancer.

M. Brandão1, C. Camacho2, C. Faustino3, N. Sousa4, J. Mauricio2 Serviço de Oncologia Médica, Instituto Portugues de Oncologia Centro do Porto (IPO-Porto), Porto, PORTUGAL Medical Oncology Department, Instituto Portugues de Oncologia Centro do Porto(IPO-Porto), Porto, PORTUGAL Medical Oncology/ Hematology, Instituto Portugues de Oncologia Centro do Porto, Porto, PORTUGAL Medical Oncology/ Hemato...

Gemcitabine and platinum-based chemotherapy in metastatic breast cancer.

Although anthracyclines and the taxanes comprise the most active first-line cytotoxic treatments in patients with hormone-insensitive or life-threatening metastatic breast cancer, many patients progress and require other chemotherapeutic agents. Development of new combinations and/or agents is thus needed. Gemcitabine (Gemzar) and platinum compounds have been employed as single agents, and the ...

Gemcitabine Plus Platinum Combination Chemotherapy for Elderly Patients with Advanced Non-small Cell Lung Cancer: A Retrospective Analysis

PURPOSE This study aimed to analyze the efficacy and toxicity of gemcitabine plus platinum chemotherapy for patients aged 70 years or older with advanced non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS We reviewed the records of stage IIIB, IV NSCLC patients or surgically inoperable stage II, IIIA NSCLC patients who were aged 70 years or older when treated with gemcitabine (1,250 mg...

Irinotecan/gemcitabine combination chemotherapy in pancreatic cancer.

Gemcitabine (Gemzar) and irinotecan (CPT-11, Camptosar) are active cytotoxic drugs against pancreatic cancer. Preclinical data evaluating the combination of gemcitabine and irinotecan suggest dose-dependent synergistic interactions in SCOG small-cell lung cancer and MCF-7 breast cancer cell lines. Two phase I trials of this combination have been reported to date: the day 1 and 8 every-3-week sc...

Author ' s response to reviews Title : Gemcitabine versus gemcitabine based combination chemotherapy in advanced pancreatic cancer